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Updated: Jun 1, 2025

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
Published on: September 9, 2016
Structural and theoretical studies of amantadinium fenamates
Marta S Krawczyk1, Monika K Krawczyk2, Irena Majerz3
1Faculty of Pharmacy, Department of Basic Chemical Sciences, Wroclaw Medical University, Borowska 211A, Wrocław, 50-556, Poland.
Abstract:
Two new crystals of amantadinium salts were obtained from fenamic and tolfenamic acid. The salt of fenamic acid is a model compound for interaction analysis, while amantadinium tolfenamate is a composition of a drug used in the treatment of symptoms of Parkinsonism and as a nonsteroidal anti-inflammatory drug. The crystal structures were studied and a theoretical analysis of the hydrogen bonds and weak interactions was carried out using quantum theory of atoms in molecules (QTAIM) and non-covalent interaction (NCI) methods.
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