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Related Experiment Video

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Hexagonal Hollow Core PCF-Based Blood Components Sensing: Design and Simulation.

Md Alamin Hossain1, Md Parash Chowdhury1, Md Mahabub Hossain2

  • 1Department of Electronics and Communication Engineering, Hajee Mohammad Danesh Science and Technology University, Dinajpur, 5200, Bangladesh.

Cell Biochemistry and Biophysics
|January 21, 2025
PubMed
Summary

A novel photonic crystal fiber sensor precisely detects blood components like white blood cells, red blood cells, hemoglobin, and platelets. This advanced biosensor offers high sensitivity and low loss, promising breakthroughs in medical diagnostics and optical communications.

Keywords:
BiosensorBlood componentsEMLOptimizePCFRelative sensitivity

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Area of Science:

  • Biomedical Engineering
  • Optical Sensing
  • Materials Science

Background:

  • Accurate detection of blood components is vital for medical diagnostics and overall health.
  • Existing methods may lack the sensitivity or specificity required for comprehensive blood analysis.
  • Photonic Crystal Fibers (PCFs) offer unique light-confining properties suitable for advanced sensing applications.

Purpose of the Study:

  • To develop and evaluate a novel PCF-based sensor for the precise identification of multiple blood components.
  • To assess the sensor's sensitivity, effective area, and confinement loss for key blood analytes.
  • To explore the potential of this biosensor in medical diagnostics and optical communication systems.

Main Methods:

  • Design of a hexagonal hollow-core PCF sensor with a circled air hole, operating between 1.0 µm and 3.0 µm.
  • Numerical analysis using COMSOL Multiphysics to simulate and assess sensor performance.
  • Fabrication of the PCF structure using 3D printing with Teflon as the background material.

Main Results:

  • Achieved high relative sensitivity: ~97.45% for WBCs, ~99.13% for HB, ~99.61% for RBCs, ~93.44% for plasma, and ~99.42% for platelets at 1 µm.
  • Demonstrated low confinement loss values, e.g., 3.032×10⁻⁹ dB/m for WBCs and 2.947×10⁻⁹ dB/m for HB.
  • Obtained specific effective areas for each blood component, indicating efficient light-matter interaction.

Conclusions:

  • The developed PCF sensor exhibits outstanding sensitivity and low loss, making it highly suitable for accurate blood component detection.
  • The sensor's innovative design and performance characteristics position it as a valuable tool for both medical diagnostics and optical communication.
  • The use of 3D printing facilitates the fabrication of this advanced biosensor, paving the way for its practical implementation.