Clinicopathological and prognostic significance of stromal p16 and p53 expression in oral squamous cell carcinoma

Yusuke Amano ¹, Masayo Hasegawa ², Atsushi Kihara ³

¹Division of Tumor Pathology, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, Tochigi, Japan; Department of Pathology, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, Tochigi, Japan.
²Department of Pathology, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, Tochigi, Japan; Department of Otolaryngology-Head and Neck Surgery, Jichi Medical University Saitama Medical Center, 1-847, Amanumacho, Omiya-ku, Saitama, Japan.
³Division of Tumor Pathology, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, Tochigi, Japan; Department of Pathology, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, Tochigi, Japan; Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama, Kanagawa, Japan.
⁴Department of Pathology, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, Tochigi, Japan; Department of Pathology, Faculty of medicine, University of Tsukuba, 1-1-1, Tennoudai, Tsukuba, Ibaraki, Japan.
⁵Department of Pathology, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, Tochigi, Japan.
⁶Department of Otolaryngology, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, Tochigi, Japan.
⁷Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University Saitama Medical Center, 1-847, Amanumacho, Omiya, Saitama, Saitama, Japan.
⁸Division of Tumor Pathology, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, Tochigi, Japan; Department of Pathology, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, Tochigi, Japan; Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, 3-8-31, Ariake, Koto-ku, Tokyo, Japan.

⁰Division of Tumor Pathology, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, Tochigi, Japan; Department of Pathology, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, Tochigi, Japan.

Annals of Diagnostic Pathology +

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January 21, 2025

View abstract on PubMed

Summary

Stromal p16 and p53 positivity in oral squamous cell carcinoma (OSCC) correlate with aggressive features and poor prognosis. These biomarkers may regulate tumor aggressiveness, offering potential prognostic insights for OSCC patients.

Area Of Science

Oncology
Cancer Biology
Pathology

Background

The tumor microenvironment is complex, comprising neoplastic and stromal cells.
The roles of p16 and p53 in oral squamous cell carcinoma (OSCC) stroma are not well understood.
Understanding stromal markers is crucial for predicting OSCC progression.

Purpose Of The Study

To investigate the expression and prognostic significance of p16 and p53 in the stromal cells of OSCC.
To determine the association of stromal p16 and p53 with clinicopathological features and patient outcomes.

Main Methods

Immunohistochemical analysis of p16 and p53 expression in 116 OSCC tissue samples.
Correlation of protein expression with histological grade, invasion patterns, and patient survival.
Multivariate analysis to identify independent prognostic factors.

Main Results

p16-positive stromal cells were found in 74 samples; p53-positive stromal cells in 33 samples.
Both p16 and p53 positivity were linked to higher histological grade, lymphovascular invasion, immature stroma, and infiltrative patterns.
Stromal p16 and p53 positivity were independent predictors of poor overall survival.

Conclusions

Stromal p16 and p53 expression are associated with aggressive OSCC phenotypes.
These markers serve as independent prognostic factors for overall survival in OSCC patients.
Stromal p16 and p53 positivity may play a regulatory role in OSCC tumor aggressiveness.

Keywords:

Oral squamous cell carcinoma Prognosis Stromal pattern p16 p53

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