The adaptive value of recombination in resolving intralocus sexual conflict by gene duplication

Recombination plays a key role in increasing the efficacy of selection. We investigate whether recombination can also play a role in resolving adaptive conflicts at loci coding for traits shared between the sexes. Errors during recombination events resulting in gene duplications may provide a long-term evolutionary advantage if those loci also experience sexually antagonistic (SA) selection since, after duplication, sex-specific expression profiles will be free to evolve, thereby reducing the load on population fitness and resolving the conflict. The potential advantage of gene duplication may be tempered by the short-term deleterious effects on gamete and zygote survival, which may be tolerable in a species with high reproductive output but not with low reproductive output. We used datasets of candidate SA loci from Drosophila melanogaster and humans to test these ideas. As in humans, sexually antagonistic alleles in flies with net positive effects across the two sexes occurred at higher frequencies than alleles with net negative effects. In flies, higher recombination rates were associated with more intense levels of sexual conflict and genes with paralogues occur in regions with higher recombination rates, indicating gene duplication events are associated with a history of SA selection. Genes experiencing higher levels of conflict also showed both a higher proportion with paralogues and higher numbers of paralogues. Together, our findings reveal multiple lines of evidence for a possible route towards the resolution of an adaptive conflict via gene duplication that is facilitated by higher recombination rates.