Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Statistical Methods for Analyzing Epidemiological Data01:25

Statistical Methods for Analyzing Epidemiological Data

294
Epidemiological data primarily involves information on specific populations' occurrence, distribution, and determinants of health and diseases. This data is crucial for understanding disease patterns and impacts, aiding public health decision-making and disease prevention strategies. The analysis of epidemiological data employs various statistical methods to interpret health-related data effectively. Here are some commonly used methods:
294
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

50
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
50
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
Hormonal Regulation01:33

Hormonal Regulation

32.9K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
32.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predicting ankylosing spondylitis disease activity via patient-reported outcome measures: Building prediction models based on machine learning.

PloS one·2026
Same author

Hemoglobin predicts mortality risk in geriatric patients with dysphagia: a Japanese retrospective cohort study.

Frontiers in nutrition·2026
Same author

Development of efficient genetic toolkits and heterologous chassis for bioprospecting of myxobacteria.

Nature communications·2026
Same author

[A bidirectional feature mapping classification model based on multi-constrained latent representation learning for differential diagnosis of pneumonia].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University·2026
Same author

Injury and repair in limb deformities associated with peripheral neuropathy: Visualization analyses of research trends and hotspots.

Neural regeneration research·2026
Same author

Pulse pressure mediation and hypertension modulation: the impact of TyG index on renal function deterioration in CKD patients under the CKM syndrome framework.

Frontiers in endocrinology·2026

Related Experiment Video

Updated: Jun 1, 2025

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
06:07

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

Published on: October 22, 2020

6.3K

Smoking as a causative factor in chronic kidney disease: a two-sample Mendelian randomization study.

Yue Yang1, Zheng Zhang1, Hai-Tao Lu1

  • 1Department of Nephrology, China-Japan Friendship Hospital, Beijing, China.

Renal Failure
|January 21, 2025
PubMed
Summary

Smoking significantly increases the risk of developing chronic kidney disease (CKD). Quitting smoking offers a protective effect, highlighting the importance of smoking cessation for kidney health.

Keywords:
Mendelian randomizationSmokingcausationchronic kidney diseasegenetic analysis

More Related Videos

Isolation of Mouse Respiratory Epithelial Cells and Exposure to Experimental Cigarette Smoke at Air Liquid Interface
10:47

Isolation of Mouse Respiratory Epithelial Cells and Exposure to Experimental Cigarette Smoke at Air Liquid Interface

Published on: February 21, 2011

34.0K
Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice
10:37

Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice

Published on: January 16, 2015

13.2K

Related Experiment Videos

Last Updated: Jun 1, 2025

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
06:07

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

Published on: October 22, 2020

6.3K
Isolation of Mouse Respiratory Epithelial Cells and Exposure to Experimental Cigarette Smoke at Air Liquid Interface
10:47

Isolation of Mouse Respiratory Epithelial Cells and Exposure to Experimental Cigarette Smoke at Air Liquid Interface

Published on: February 21, 2011

34.0K
Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice
10:37

Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice

Published on: January 16, 2015

13.2K

Area of Science:

  • Genetics and Epidemiology
  • Public Health
  • Nephrology

Background:

  • Smoking is a known health risk, but its direct causal link to chronic kidney disease (CKD) requires further investigation.
  • Understanding the specific smoking behaviors associated with CKD is crucial for public health interventions.

Purpose of the Study:

  • To investigate the causal relationship between various smoking behaviors and the risk of developing CKD.
  • To determine the impact of smoking initiation, cessation, intensity, and duration on CKD incidence.

Main Methods:

  • Utilized bivariate causal analysis and two-sample Mendelian randomization (MR) with genome-wide data.
  • Employed inverse variance weighted (IVW) method, sensitivity analyses, pleiotropy assessments, and mediation analyses.
  • Validated findings using independent external datasets.

Main Results:

  • Confirmed positive associations between CKD and smoking initiation, earlier age of initiation, higher daily cigarette consumption, and lifetime smoking.
  • Demonstrated a significant protective effect of smoking cessation against CKD.
  • Identified body mass index, cardiovascular disease, hypertension, and type 2 diabetes as mediators of smoking's effect on CKD.

Conclusions:

  • Establishes smoking as a significant contributing factor to the development of CKD.
  • Supports public health strategies focused on smoking reduction and cessation to decrease CKD prevalence.