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Updated: Jun 1, 2025

Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood
Published on: February 5, 2020
What should intensivists know about immune checkpoint inhibitors and their side effects?
Viktor Yordanov Zlatkov Aleksandrov1, Fernando Martínez Sagasti1, Juncal Pérez-Somarriba Moreno1
1Hospital Clínico San Carlos, C. Profesor Martín Lagos SN, Madrid, 28040, Spain.
Abstract:
The pharmacological group of immune checkpoint-inhibitors (ICI) has revolutionized the field of oncology in the last ten years. The improvements in the survival of certain cancers thanks to these treatments comes at the cost of an increased morbidity and mortality due to certain immune related adverse events (irAE). This review will concentrate on the irAE that more frequently require intensive care unit (ICU) admission. The infectious burden of patients treated with ICI is also explored, shining light not only on the infections caused by the immunosuppression needed to manage the different irAE, but also on the specific infections arising from a unique immune dysregulation only seen in ICI treated patients.
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