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Updated: Jun 1, 2025

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
High-performance anionic stereogenic-at-cobalt(III) complex/halide salts/oxone catalytic system for enantioselective
Yi-Jun Fang1, Xiao-Bao Wu1, Qi-Ming Wang1
1Department of Applied Chemistry, Anhui Province Engineering Laboratory for Green Pesticide Development and Application, and Anhui Province Key Laboratory of Crop Integrated Pest Management, Anhui Agricultural University, Hefei 230036, China. jieyu@ahau.edu.cn.
Abstract:
A high-performance anionic stereogenic-at-cobalt(III) complex/oxone catalytic system was developed for various enantioselective intramolecular halocyclizations of olefins using halide salts as halogen sources, delivering structurally diverse halogenated heterocyclic compounds with outstanding stereoselectivity (up to 97 : 3 e.r.). In this protocol, ultra-low catalyst loadings can be routinely used, since the stereogenic-at-cobalt(III) complexes were the sole counteranions of cationic halonium intermediates, minimizing background reactions to the greatest extent possible.
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