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Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
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Sertraline in depressed patients with or at risk for coronary heart disese: a systemic review

Kiana Seifouri1, Reza Kahdemi2, Fatemeh Ahmadi Hajikolaei3

  • 1Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences Tehran, Iran.

American Journal of Cardiovascular Disease
|January 22, 2025
PubMed

Insights

Serotonin-targeting antidepressants may benefit patients with coronary heart disease (CHD) by improving depression and reducing cardiovascular risks. This systematic review supports their use in high-risk populations.

Area of Science:

  • Cardiology
  • Psychiatry
  • Pharmacology

Background:

  • Depression is common in patients with coronary heart disease (CHD).
  • Evidence linking antidepressants like sertraline to CHD outcomes is inconclusive.
  • A systematic review was conducted to clarify this association.

Purpose of the Study:

  • To systematically review the evidence on the effects of serotonin-targeting antidepressants in patients with CHD.
  • To assess the impact of these medications on both depressive symptoms and cardiovascular events.

Main Methods:

  • A systematic literature search was performed across PubMed, Google Scholar, and Scopus up to March 2023.
  • 12 studies, including 11 randomized controlled trials (RCTs) and one pilot study, were included after screening.
  • The review analyzed data from 2767 participants with major depressive disorder and cardiovascular disease or risk.

Main Results:

  • Most studies showed improved mood status with serotonin-targeting antidepressants.
  • A reduced risk of cardiovascular events was observed in treated patients.
  • Observed cardiac side effects with serotonin treatment did not reach statistical significance.

Conclusions:

  • Serotonin-targeting antidepressants demonstrate beneficial effects on depressive symptoms in CHD patients.
  • These medications may also help prevent adverse coronary outcomes.
  • Findings support the use of serotonin-based treatments for depression in high-risk cardiovascular populations.
Abstract

Keywords:
DepressionSSRIscardiac diseasecoronary heart diseasesertraline

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