Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic Diversity in Coppice Chestnut Forests in Central Italy and Potential Use of SSR-Based Timber Traceability.

Plants (Basel, Switzerland)·2026
Same author

Impact of BRAF inhibitors on surgical outcomes in melanoma brain metastases: Evidence from a multicenter observational study.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026
Same author

Identification of a long-term surviving human mesenchymal stromal cell subpopulation and implications for recessive dystrophic epidermolysis bullosa treatment.

Stem cell research & therapy·2026
Same author

Positional Hemodynamic Instability in a Patient With Pectus Excavatum Undergoing Lumbar Discectomy.

Cureus·2026
Same author

Safety and effectiveness of setmelanotide in young patients with severe obesity due to craniopharyngioma: a real world monocentric experience.

Journal of endocrinological investigation·2026
Same author

Perioperative aspirin discontinuation prior to burr-hole drainage for chronic subdural hematoma: A European multicenter retrospective cohort study.

Clinical neurology and neurosurgery·2026

Related Experiment Video

Updated: Jun 1, 2025

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

3.5K

Preoperative mapping techniques for brain tumor surgery: a systematic review.

Augusto Leone1,2, Francesco Carbone2,3, Uwe Spetzger2

  • 1Department of Neurosurgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Frontiers in Oncology
|January 22, 2025
PubMed
Summary

Navigated transcranial magnetic stimulation (nTMS) offers accurate preoperative brain mapping for tumor surgery. It provides reliable motor and language assessments, unlike functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG).

Keywords:
brain mappingbrain tumor surgeryfMRIlanguage eloquent tumormagnetoencephalography (MEG)motor eloquent tumorsnavigated transcranial magnetic stimulation (nTMS)preoperative mapping

More Related Videos

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

45.0K
Study Design for Navigated Repetitive Transcranial Magnetic Stimulation for Speech Cortical Mapping
09:16

Study Design for Navigated Repetitive Transcranial Magnetic Stimulation for Speech Cortical Mapping

Published on: March 24, 2023

1.3K

Related Experiment Videos

Last Updated: Jun 1, 2025

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

3.5K
Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

45.0K
Study Design for Navigated Repetitive Transcranial Magnetic Stimulation for Speech Cortical Mapping
09:16

Study Design for Navigated Repetitive Transcranial Magnetic Stimulation for Speech Cortical Mapping

Published on: March 24, 2023

1.3K

Area of Science:

  • Neurosurgery
  • Neuroimaging
  • Brain Mapping

Background:

  • Accurate preoperative brain mapping is essential for maximizing tumor resection and preserving neurological function.
  • Navigated transcranial magnetic stimulation (nTMS), magnetoencephalography (MEG), and functional magnetic resonance imaging (fMRI) are used for motor and language mapping.

Purpose of the Study:

  • To systematically review and analyze the reliability, clinical utility, and accessibility of nTMS, MEG, and fMRI for preoperative brain mapping.
  • To compare the effectiveness of these neuroimaging techniques in guiding brain tumor surgery.

Main Methods:

  • Systematic review following PRISMA guidelines.
  • Analysis of 128 studies (48 nTMS, 56 fMRI, 24 MEG) from multiple databases.
  • Comparison of techniques against direct cortical stimulation where applicable.

Main Results:

  • nTMS demonstrates high accuracy and safety for preoperative motor mapping, outperforming fMRI in assessing motor deficits when combined with tractography.
  • fMRI presents limitations due to potential false positives and negatives, restricting its preoperative planning utility.
  • MEG shows high motor mapping accuracy but is limited by cost and complexity.
  • Language mapping shows variability; repetitive nTMS offers valuable negative predictive value for surgical planning.

Conclusions:

  • nTMS is a reliable and accurate tool for preoperative motor and language mapping in neurosurgery.
  • fMRI has limitations for preoperative planning, while MEG's application is constrained by resources.
  • Further multicenter studies are needed to validate language mapping techniques and establish broader clinical recommendations.