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Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
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Alzheimer's disease and infectious agents: a comprehensive review of pathogenic mechanisms and microRNA roles

Seyyed Sam Mehdi Hosseininasab1, Rasoul Ebrahimi2, Shirin Yaghoobpoor2

  • 1Critical Care Quality Improvement Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Frontiers in Neuroscience
|January 22, 2025
PubMed

Insights

Infections from viruses and bacteria are increasingly linked to Alzheimer's Disease (AD) pathogenesis. Understanding these pathogen mechanisms is crucial for future AD research and potential interventions.

Area of Science:

  • Neuroscience
  • Infectious Diseases
  • Pathology

Background:

  • Alzheimer's Disease (AD) is the leading cause of dementia, marked by senile plaques and neurofibrillary tangles.
  • The role of infectious agents in AD pathogenesis is an emerging and significant area of research.
  • Numerous viruses (e.g., HSV-1, EBV, SARS-CoV-2) and bacteria (e.g., CP, HP, P. gingivalis) have been associated with AD.

Purpose of the Study:

  • To provide an overview of the association between Alzheimer's Disease and various infectious agents.
  • To focus on the specific mechanisms by which these pathogens may contribute to AD pathogenesis.
  • To highlight key areas for future research in this field.

Main Methods:

  • Literature review and synthesis of existing research on infectious agents and Alzheimer's Disease.
  • Analysis of proposed mechanisms linking pathogens to AD, including immune activation, inflammation, and oxidative stress.
  • Exploration of the role of microRNAs (miRNAs) in pathogen-host interactions within the context of AD.

Main Results:

  • Multiple infectious agents, including viruses, bacteria, and parasites, have been implicated in AD.
  • These pathogens can trigger immune responses, inflammation, and oxidative stress, contributing to neurodegeneration.
  • MicroRNAs are identified as key regulators in pathogen-host interactions and may influence AD development.

Conclusions:

  • A growing body of evidence links infectious agents to Alzheimer's Disease.
  • Understanding the intricate mechanisms of pathogen involvement is essential for developing novel therapeutic strategies.
  • Further research is warranted to fully elucidate the role of infections in AD and to explore preventative or treatment options.
Keywords:
Alzheimer’s diseasebacterial infectionparasitepathogenviral infection

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