Related Experiment Video
Updated: May 31, 2025
The Plant Infection Test: Spray and Wound-Mediated Inoculation with the Plant Pathogen Magnaporthe Grisea
Published on: August 4, 2018
Polyprenylated Xanthones Isolated from Garcinia Resins and Their Beneficial Effects on Rice Blast Disease
Ke-Ming Li1,2, Shu-Min Zheng1, Xian Dong3
1Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, Marshall Laboratory of Biomedical Engineering, Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, People's Republic of China.
Abstract:
Five undescribed polyprenylated xanthones (1, 3, 4, 22, and 23) and 27 known compounds were isolated from Garcinia resins, and the antifungal activities of 15 of them were investigated. Compound 7 exhibited notable in vitro antifungal effects against Magnaporthe grisea with an IC50 value of 3.54 μg/mL, superior to isoprothiolane (10.30 μg/mL), and showed an excellent protective efficiency of 78.4% at 200 μg/mL against RB (rice blast), equivalent to isoprothiolane (87.2%). Its antifungal activity may be related to the destruction of the cell membrane and the effect of absorption and utilization of sugar by the mycelium, which was proven by the transcriptome sequencing and preliminary mechanism, showing a good application prospect for replacing agrochemical fungicides in the control of RB disease.
