Related Experiment Video
Updated: May 31, 2025
09:38
Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
Published on: September 12, 2016
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[Neurological side-effects associated with immune checkpoint inhibitors]
Wouter W van Willigen1,2, Dieuwke A Schreurs3, Frank M Speetjens4
1Leids Universitair Medisch Centrum, afd. Interne Geneeskunde, Leiden.
Nederlands Tijdschrift Voor Geneeskunde
|January 22, 2025
Summary
Checkpoint inhibitors offer cancer benefits but can cause immune-related adverse events (irAEs). Neurological irAEs present diverse symptoms, challenging diagnosis and requiring prompt recognition to prevent severe outcomes.
Area of Science:
- Oncology
- Immunology
- Neurology
Background:
- Checkpoint inhibitors (CPIs) are crucial in cancer therapy, improving outcomes.
- CPIs are associated with immune-related adverse events (irAEs).
- Neurological irAEs (neuro-irAEs) are a subset of irAEs with diverse presentations.
Purpose of the Study:
- To highlight the diagnostic challenges of neuro-irAEs.
- To illustrate the varied clinical manifestations of neuro-irAEs.
- To emphasize the importance of recognizing neuro-irAEs in patients receiving CPIs.
Main Methods:
- Case series presentation.
- Review of clinical symptoms and diagnostic considerations.
- Discussion of differential diagnoses for neuro-irAEs.
Main Results:
- Presented three distinct cases of neuro-irAEs.
- Demonstrated varied symptoms including muscle weakness, sensory disturbances, seizures, and diplopia.
- Highlighted diagnostic difficulties due to symptom mimicry of disease progression or other neurological conditions.
Conclusions:
- Neuro-irAEs require high clinical suspicion due to their diverse and often non-specific symptoms.
- Prompt diagnosis and management of neuro-irAEs are critical to avoid severe neurological complications.
- Healthcare providers must be aware of neuro-irAEs in the context of increasing CPI utilization.
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