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Updated: Jun 5, 2026

An In Vitro Organ Culture Model of the Murine Intervertebral Disc
Published on: April 11, 2017
Finite element models of intervertebral disc: recent advances and prospects
Tianze Sun1,2, Junlin Wang1,2, Xin Liu1,2
1Department of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, The People's Republic of China.
Finite element (FE) models are crucial for understanding spinal biomechanics and the increasing incidence of intervertebral disc degeneration (IVDD). Advanced FE models incorporating porous materials and penetration parameters offer more realistic simulations for diagnosis and treatment.
Area of Science:
- Biomechanics
- Biomedical Engineering
- Computational Modeling
Background:
- Intervertebral disc degeneration (IVDD) incidence is rising, significantly impacting health.
- Altered biomechanical factors are primary contributors to IVDD.
- Finite element (FE) models are increasingly utilized to analyze spinal biomechanics.
Purpose of the Study:
- To review and summarize existing literature on FE models of the intervertebral disc (IVD).
- To categorize different types and construction methodologies of IVD FE models.
- To analyze the applications of representative IVD FE models.
Main Methods:
- Comprehensive literature review of studies reporting IVD FE models.
- Systematic summarization of FE model types and construction techniques.
- Analysis of applications for selected, representative FE models.
Main Results:
- Nonlinear models, accounting for porous elastic material behavior, are most prevalent.
- Advanced FE models incorporating penetration parameters are increasingly employed.
- These advanced models enhance simulation of IVD biological behavior and biomechanical properties.
Conclusions:
- Personalized FE modeling is essential for accurate diagnosis and treatment of IVDD.
- Future models should integrate microstructure, cell behavior, and complex loading conditions.
- Developing more realistic FE models is key to advancing IVDD research and clinical application.
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