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Updated: May 31, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Synthesis and characterization of heterotrimetallic Mg-Ni-Mg complexes with amidinato ligands
Rongping Zhang1, Yanping Cai1, Xin Xu1
1Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China. xinxu@suda.edu.cn.
Abstract:
Treatment of amidinato-based magnesium ethyl compounds LMgEt [L = iPr2PNC(Bu)NAr; Ar = 2,6-iPr2C6H3 (La) or 2,6-(Ph2CH)2-4-iPr-(C6H2) (Lb)] with Ni(COD)2 (COD: 1,5-cyclooctadiene) afforded heterotrimetallic Mg-Ni-Mg complexes [(LMg)2Ni(C2H4)2] through β-H elimination. These complexes exhibit approximately linear Mg-Ni-Mg linkage with the central nickel arranged in a planar configuration; the Ni(C2H4)2 unit can be considered as nickela-bis-cyclopropane. Reaction of [(LMg)2Ni(C2H4)2] with tetrahydrofuran (THF) gave a coordination product [(LMg·THF)2Ni(C2H4)2], in which the central structure remained intact and THF coordinated to two magnesium atoms respectively. In contrast, exposure of the nickela-bis-cyclopropane complex to 1 bar of CO led to the formation of a nickela-mono-cyclopropane complex [(LMg)2Ni(C2H4)(CO)2], in which two CO ligands were coordinated to the nickel center.
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