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Microfluidics Based Particle and Droplet Generation for Gene and Drug Delivery Approaches.

Deniz Onan1, Melike Özder1, Meryem İrem Sipahi1

  • 1Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Ege University, Izmir, Turkey.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
|January 22, 2025
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Summary

Microfluidic droplet technology offers precise control for biomedical research, enhancing diagnostics, drug delivery, and personalized medicine. Continued innovation is key, but commercialization challenges remain.

Keywords:
biomedical applicationsfuture perspectivesgene deliverylipid nanoparticlesmRNA vaccinesmicrofluidic droplet generationmicrofluidicsscale‐up

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Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Nanotechnology

Background:

  • Microfluidics-based droplets are a significant advancement in biomedical research.
  • They provide precise control over droplet characteristics and prevent cross-contamination.
  • Applications span diagnostics, imaging, separation, and gene amplification.

Purpose of the Study:

  • To review microfluidic droplet technology, including device aspects, generation techniques, and particle production.
  • To highlight applications in tissue engineering, cancer therapy, and drug delivery.
  • To discuss contributions to vaccines, gene therapy, and personalized medicine.

Main Methods:

  • Discussion of passive and active droplet formation methods.
  • Analysis of droplet shape and content manipulation techniques.
  • Review of microfluidics for producing lipid nanoparticles and polymeric microparticles.

Main Results:

  • Microfluidic droplets enable precise control, efficient mixing, and contamination prevention.
  • Significant potential in drug delivery systems, tissue engineering, and cancer therapy.
  • Advancements in vaccines, gene therapy, and personalized medicine are facilitated.

Conclusions:

  • Microfluidic droplet technology is crucial for advancing biomedical research and applications.
  • Integration with AI and wearable devices can further enhance personalized medicine and drug delivery.
  • Addressing commercialization and adoption challenges is essential for widespread impact.