Related Experiment Video
Updated: Aug 3, 2026
Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
Published on: January 9, 2019
Recent Advancements and Future Perspectives on Molecular Biomarkers in Adult Lower-Grade Gliomas
Jessica L Fleming1, Arnab Chakravarti
1From the Department of Radiation Oncology, Ohio State University Comprehensive Cancer Center, Columbus, OH.
Abstract:
There has been a significant paradigm shift in the clinical management of lower-grade glioma patients given the recent updates to the 2021 World Health Organization classification along with long-term results from randomized phase III clinical trials. As a result, we are now better able to diagnose and assign patients to the most appropriate treatment course. This review provides a comprehensive summary of the most robust and reliable molecular biomarkers for adult lower-grade gliomas and discusses current challenges facing this patient population that future correlative biology studies combined with advancements in technologies could help overcome.
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