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Ion Mobility Mass Spectrometry to Probe Sequences in Supramolecular Copolymers
Cédric Przybylski1,2, Patrick Brocorens3, Laetitia-Eiko Xerri3
1Sorbonne Université, CNRS, Institut Parisien de Chimie Moléculaire, IPCM, 4 place Jussieu, 75005, Paris, France.
Analyzing supramolecular copolymer sequences is challenging due to their dynamic nature. Ion mobility-mass spectrometry (IM-MS) successfully differentiates complex benzene-1,3,5-tricarboxamide (BTA) co-assembly sequences.
Area of Science:
- Supramolecular chemistry
- Analytical chemistry
- Materials science
Background:
- Supramolecular copolymers exhibit dynamic behavior, complicating microstructure analysis.
- Characterizing the precise sequence of monomers in these assemblies is crucial for understanding their properties.
Purpose of the Study:
- To develop and apply a novel method for analyzing the sequence distribution in supramolecular copolymers.
- To overcome the challenges posed by the dynamic nature of these complex systems.
Main Methods:
- Utilized ion mobility-mass spectrometry (IM-MS) to analyze benzene-1,3,5-tricarboxamide (BTA) co-assemblies.
- Employed calculated collision cross-sections to resolve isomeric sequences within the copolymer assemblies.
Main Results:
- Demonstrated the capability of IM-MS to reveal the presence of various sequences in BTA co-assemblies.
- Successfully differentiated complex isomeric sequences in hexamers, exemplified by a 4:2 monomer ratio.
Conclusions:
- IM-MS provides unprecedented insights into the sequence information of supramolecular copolymers.
- This technique offers a powerful tool for the detailed characterization of dynamic supramolecular structures.
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