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Updated: May 31, 2025

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments
Published on: January 20, 2022
Ion Mobility Mass Spectrometry to Probe Sequences in Supramolecular Copolymers
Cédric Przybylski1,2, Patrick Brocorens3, Laetitia-Eiko Xerri3
1Sorbonne Université, CNRS, Institut Parisien de Chimie Moléculaire, IPCM, 4 place Jussieu, 75005, Paris, France.
Abstract:
The analysis of the microstructure of supramolecular copolymers is difficult because of their dynamic character. Here, benzene-1,3,5-tricarboxamide (BTA) co-assemblies are analysed by ion mobility - mass spectrometry (IM-MS) to reveal the presence of various sequences. For example, the IM-MS mobilogram for hexamers composed of 4 units from a first monomer and 2 units from a second monomer is a broad distribution due to the presence of 9 possible isomeric sequences, which can be sorted out based on calculated collision cross-sections. This approach gives unprecedented information on supramolecular copolymer sequences.
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