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Published on: January 28, 2020
Serum Nitric Oxide, Endothelin-1 Correlates Post-Procedural Major Adverse Cardiovascular Events among Patients with
Huihui Guo1, Qi Qu1, Jiechao Lv1
1Department of Cardiovascular Medicine - Shengzhou People's Hospital (Shengzhou Branch of the First Affiliated Hospital of Zhejiang University School of Medicine, the Shengzhou Hospital of Shaoxing University), Zhejiang - China.
Insights
Serum nitric oxide (NO) and endothelin-1 (ET-1) levels predict major adverse cardiovascular events (MACE) in ST-segment elevation myocardial infarction (STEMI) patients after percutaneous coronary intervention (PCI). Lower NO and higher ET-1 correlate with STEMI severity.
Area of Science:
- Cardiology
- Biomarkers
- Acute Myocardial Infarction Research
Background:
- ST-segment elevation myocardial infarction (STEMI) is a severe form of acute myocardial infarction (AMI).
- Identifying prognostic markers for STEMI patients is crucial for improving outcomes.
- Major adverse cardiovascular events (MACE) remain a significant concern post-treatment.
Purpose of the Study:
- To investigate the relationship between serum nitric oxide (NO) and endothelin-1 (ET-1) levels and STEMI severity.
- To evaluate the predictive value of NO and ET-1 for MACE within one year post-percutaneous coronary intervention (PCI).
Main Methods:
- Retrospective analysis of 269 STEMI patients undergoing PCI.
- Serum NO and ET-1 levels measured via enzyme-linked immunosorbent assay.
- Receiver-operating characteristics (ROC) curve analysis for prognostic potential.
Main Results:
- Patients with MACE showed lower serum NO and higher ET-1 levels.
- A significant inverse relationship was found between NO/ET-1 levels and myocardial infarction severity.
- A combined model (-0.082 * NO + 0.059 * ET-1) showed prognostic value for MACE.
Conclusions:
- Serum NO and ET-1 levels are valuable prognostic markers for MACE in STEMI patients.
- These biomarkers correlate strongly with AMI severity.
- NO and ET-1 aid in predicting outcomes after PCI in STEMI.
Background:
ST-segment elevation myocardial infarction (STEMI) is a common and severe form of acute myocardial infarction (AMI).
Objectives:
The study aimed to investigate the relationship between serum nitric oxide (NO) and endothelin-1 (ET-1) levels with the severity of STEMI and their predictive value for major adverse cardiovascular events (MACE) within one year after percutaneous coronary intervention (PCI) in STEMI patients.
Methods:
The retrospective study was conducted on 269 STEMI patients who underwent PCI. The patients were categorized into two groups: those who developed MACE (112 cases) and those who did not (157 cases) within one year. NO and ET1 levels were measured in collected serum using enzyme-linked immunosorbent assay. Receive-operating characteristics (ROC) curve was used to analyze the prognostic potential of NO and ET1 individually and in combination, p<0.05 was considered statistically significant.
Results:
Significant differences were noted between the two groups concerning age, Killip classification, left ventricular ejection fraction, cardiac troponin I (cTnI), creatine kinase-MB (CK-MB), as well as serum NO and ET-1 levels. The study observed that patients who developed MACE had lower serum NO and higher ET-1 levels upon admission. Further analysis revealed a significant inverse relationship between serum NO and ET-1 levels and the severity of myocardial infarction. A combined detection model, -0.082 * NO + 0.059 * ET-1, demonstrated promising prognostic value for the occurrence of MACE within one year post-PCI.
Conclusions:
Serum NO and ET-1 levels serve as valuable prognostic markers for MACE in STEMI patients undergoing PCI, exhibiting a strong correlation with AMI severity.
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