Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

  1. Home
  3. Prognostic Value Of Post-treatment Extent Of Tumor (posttext) System In Patients With Hepatoblastoma.
  1. Home
  3. Prognostic Value Of Post-treatment Extent Of Tumor (posttext) System In Patients With Hepatoblastoma.

Related Experiment Video

The Influence of Liver Resection on Intrahepatic Tumor Growth
07:55

The Influence of Liver Resection on Intrahepatic Tumor Growth

Published on: April 9, 2016

9.4K

Prognostic Value of POST-Treatment Extent of Tumor (POSTTEXT) System in Patients with Hepatoblastoma.

Hana Jeong1, Hee Mang Yoon1, Pyeong Hwa Kim1

  • 1Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Cancer Research and Treatment
|January 22, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Post-treatment AFP levels and tumor size changes are key predictors of event-free survival in hepatoblastoma. Combining these factors with the CHIC-HS system improves prognostic accuracy for pediatric liver cancer patients.

Keywords:
ChemotherapyHepatoblastomaMetastasis

More Related Videos

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis
07:32

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

1.2K
A Hepatocellular Cancer Patient-Derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth
08:15

A Hepatocellular Cancer Patient-Derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth

Published on: February 2, 2024

727

Related Experiment Videos

The Influence of Liver Resection on Intrahepatic Tumor Growth
07:55

The Influence of Liver Resection on Intrahepatic Tumor Growth

Published on: April 9, 2016

9.4K
Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis
07:32

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

1.2K
A Hepatocellular Cancer Patient-Derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth
08:15

A Hepatocellular Cancer Patient-Derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth

Published on: February 2, 2024

727

Area of Science:

  • Pediatric Oncology
  • Hepatobiliary Malignancies
  • Diagnostic Imaging

Background:

  • Hepatoblastoma is the most common pediatric liver cancer.
  • Neoadjuvant chemotherapy is a standard treatment approach.
  • Accurate prognostication is crucial for treatment stratification and outcomes.

Purpose of the Study:

  • To evaluate the prognostic value of the POSTTEXT system and clinical factors post-neoadjuvant chemotherapy in hepatoblastoma.
  • To assess the added benefit of posttreatment imaging and clinical factors to the CHIC-HS system.

Main Methods:

  • Retrospective analysis of 73 hepatoblastoma patients treated with neoadjuvant chemotherapy.
  • Inclusion of pre- and post-treatment imaging and clinical data, including AFP levels.
  • Cox regression and time-dependent ROC analyses to identify predictors of event-free survival (EFS).

Main Results:

  • Post-chemotherapy AFP levels, tumor size change ratio, and POSTTEXT metastasis (M) were significant EFS predictors.
  • POSTTEXT demonstrated superior inter-reader agreement compared to PRETEXT.
  • Integration of post-chemotherapy AFP levels into the CHIC-HS system enhanced predictive power.

Conclusions:

  • Post-treatment AFP levels and tumor size are critical prognostic indicators in hepatoblastoma.
  • The POSTTEXT system offers reliable assessment of tumor extent.
  • Combining clinical factors with risk stratification systems like CHIC-HS improves prognostic accuracy for hepatoblastoma.