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Updated: May 31, 2025

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Importance of integrin transmembrane helical interactions for antagonistic versus agonistic ligand behavior:

Ute Reuning1, Vincenzo Maria D'Amore2, Kairbaan Hodivala-Dilke3

  • 1TUM University Hospital, Klinikum Rechts der Isar, School of Medicine and Health, Technical University of Munich, Department of Gynecology and Obstetrics, Clinical Research Unit, Ismaninger Strasse 22, 81675 Munich, Germany.

Bioorganic Chemistry
|January 22, 2025
PubMed

Keywords:
AgonistAntagonistDose-dependent functional switchFocal adhesionsIntegrin conformational activation and signalingIntegrin ligandsIntegrinsTransmembrane domains

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