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Updated: May 31, 2025

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Chemogenetic modulation of parathyroid hormone secretion alleviates osteoporosis in ovariectomized rats
Yutong Xiao1, Qian Yuan2, Fan Yang2
1Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, Guangdong, China.
Abstract:
Parathyroid hormone (PTH) is critical for regulating calcium and phosphate homeostasis, and its dysregulation contributes to osteoporosis. Current methods for precise control of PTH secretion are limited. This study explores chemogenetic tools to regulate PTH secretion in parathyroid chief cells via Gq/Gi signaling. In vitro, we found that activation of hM3Dq-expressing cells increased PTH release, while hM4Di inhibited it. In vivo, hM3Dq activation improved bone structure and reduced bone loss in an ovariectomized rat model. These findings suggest chemogenetics as a promising approach for modulating PTH and offering potential therapeutic strategies for bone health and related disorders.
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