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Behavioral adaptations after unilateral whisker denervation.

Patrick Wright1, Eleanor McCall2, Sean Collier3

  • 1National Institute of Neurological Disorders and Stroke (NINDS) Intramural Program, Bethesda, MD, USA.

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Summary

Mice with one-sided whisker loss adapt by favoring intact whiskers for object inspection. However, they show impaired gap crossing and increased anxiety, which can be improved with task-specific training.

Keywords:
Anxiety after injuryMouse behaviorWhisker denervation/deprivationWhisker task

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Area of Science:

  • Neuroscience
  • Sensory systems biology
  • Animal behavior

Background:

  • The rodent whisker system is a key model for studying neural plasticity.
  • Rodents rely on bilateral whiskers for environmental sensing.
  • The behavioral consequences of unilateral whisker denervation are not well understood.

Purpose of the Study:

  • To investigate the impact of unilateral whisker denervation on sensorimotor behaviors in mice.
  • To explore adaptive strategies and potential behavioral deficits following whisker loss.
  • To assess the role of experience-dependent plasticity in response to whisker system alterations.

Main Methods:

  • Adult mice underwent unilateral whisker denervation.
  • Behavioral assessments included object inspection, open field navigation, object localization, and gap crossing tasks.
  • Anxiety-like behaviors were evaluated.
  • The effect of gap crossing task training on anxiety was assessed.

Main Results:

  • Mice preferred using intact whiskers for object inspection but showed no change in open field navigation.
  • Object localization performance was unaffected, but gap crossing ability was significantly impaired.
  • Chronic whisker denervation resulted in increased anxiety-like behavior.
  • Training on the gap crossing task successfully rescued anxiety-like behaviors.

Conclusions:

  • Mice employ behavioral strategies to compensate for unilateral whisker loss.
  • Whisker system damage impacts specific sensorimotor functions like gap crossing and induces anxiety.
  • Targeted behavioral training can mitigate negative emotional consequences of sensory system disruption.