Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Overview of Exosomes

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Photo-switchable supramolecular glycochips for capturing suspension tumor cells and real-time profiling of cell surface glycosylation.

The Analyst·2026

Same author

Rougan Granules ameliorates liver fibrosis through autophagy regulation: Insights from HPLC-Q-TOF-MS/MS, network pharmacology, and experimental validation.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences·2026

Same author

Point-of-care SERS platforms: integrating microfluidics and machine learning for disease screening.

Lab on a chip·2026

Same author

Enhancing flood prediction through physics-driven typhoon feature engineering and machine learning.

PloS one·2026

Same author

Deep learning-empowered SERS: deciphering the multidimensional information code of complex biological samples.

Analytical methods : advancing methods and applications·2026

Same author

Global inequities in organ transplantation, 2008-2023: trends, unmet need, and policy implications.

EClinicalMedicine·2026

Search research articles

Related Experiment Video

Updated: May 31, 2025

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

Surface-Enhanced Raman Scattering (SERS) for exosome detection.

Biqing Chen¹, Xiaohong Qiu¹

¹Gynaecology and Obstetrics, The Second Affiliated Hospital of Harbin Medical University, Harbin Medical University, Heilongjiang 150081 PR China.

Clinica Chimica Acta; International Journal of Clinical Chemistry

|January 22, 2025

Summary

This summary is machine-generated.

Surface-Enhanced Raman Scattering (SERS) offers a sensitive method for detecting exosomes, crucial for early disease diagnosis. This technology overcomes limitations of traditional methods, enabling faster and more accurate detection without large sample volumes.

Keywords:

Biological Modification Detection Diagnosis Exosomes Surface-Enhanced Raman Scattering (SERS)

More Related Videos

Fabricating a UV-Vis and Raman Spectroscopy Immunoassay Platform

Fabricating a UV-Vis and Raman Spectroscopy Immunoassay Platform

Published on: November 10, 2016

An Innovative Method for Exosome Quantification and Size Measurement

An Innovative Method for Exosome Quantification and Size Measurement

Published on: January 17, 2015

Related Experiment Videos

Last Updated: May 31, 2025

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

Fabricating a UV-Vis and Raman Spectroscopy Immunoassay Platform

Fabricating a UV-Vis and Raman Spectroscopy Immunoassay Platform

Published on: November 10, 2016

An Innovative Method for Exosome Quantification and Size Measurement

An Innovative Method for Exosome Quantification and Size Measurement

Published on: January 17, 2015

Area of Science:

Biotechnology
Nanotechnology
Analytical Chemistry

Background:

Exosomes are nanoscale extracellular vesicles found in biological fluids, carrying molecules relevant for early disease detection.
Current exosome detection methods face challenges like large sample volume requirements and complex analysis.
Limitations in traditional methods hinder the clinical application of exosome-based diagnostics.

Purpose of the Study:

To review the application of Surface-Enhanced Raman Scattering (SERS) for exosome detection.
To highlight SERS's potential in overcoming current challenges in exosome analysis.
To explore SERS for real-time, non-invasive exosome assessment for early disease diagnosis.

Main Methods:

Review of existing literature on SERS technology and exosome detection.
Analysis of SERS's photonic properties and high sensitivity for biomarker identification.
Focus on SERS's capability for label-free and minimal-sample-volume exosome analysis.

Main Results:

SERS provides a sensitive and specific platform for exosome detection.
The technology enables detection without extensive sample enrichment or phenotypic analysis.
SERS facilitates real-time and non-invasive assessment of exosomes.

Conclusions:

SERS-based exosome detection holds significant promise for advancing early disease diagnosis.
This technology can overcome existing limitations, leading to more effective diagnostic assays.
SERS contributes to personalized medicine and improved patient outcomes through enhanced diagnostics.