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Updated: May 31, 2025
Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
Published on: February 7, 2017
Rational design and analytical characterization of self-assembling poly(N‑isopropylacrylamide) and
Mirko Bonelli1, Eric Allémann2, Mauro Di Stefano3
1Novartis Pharma AG, GDD, TRD Biologics & CGT 4002 Basel, Switzerland; School of Pharmaceutical Sciences, University of Geneva CH-1206 Geneva, Switzerland.
Abstract:
In this study, we applied a systematic approach to establish an iterative workflow and to drive the chemical design of thermosensitive, in situ forming injectables as a function of the intended target product profile. Self-assembly, mechanical properties, physical state, and thermal transition behavior were assessed via nuclear magnetic resonance, oscillatory rheology, turbidimetry and visual inspection techniques. Thus, poly(N-isopropylacrylamide) (PNIPAM) and poly(2-alkyl-2-oxazoline)s (PAOx)s with LCSTs below body temperature were studied before and after grafting them onto azido-substituted hyaluronic acid (HA) via strain-promoted azide-alkyne cycloaddition (SPAAC). Ultimately, we identified critical material attributes able to guide the pharmaceutical development of in situ gelling thermosensitive polymers.
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