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Aspergixanthones L-T, nine undescribed prenylxanthone derivatives from Aspergillus stellatus
Yu Liang1, Xuanni Chen2, Qin Li2
1Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Department of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China.
Abstract:
Nine undescribed prenylxanthone derivatives, aspergixanthones L-T (1-9), were isolated from the fungus Aspergillus stellatus. Compound 4 represents the first propionylated prenylxanthone, while compounds 7-9 are the first examples of prenylxanthones adorned with a 2,3-butanediol group. Their structures with absolute configurations were elucidated based on comprehensive spectroscopic analyses, ECD calculation, single-crystal X-ray diffraction, Mo2(OAc)4 induced ECD experiment, and Mosher's method. Compound 9 showed cytotoxic effects against several human cancer cell lines with the IC50 values ranging from 3.35 ± 0.58 to 8.62 ± 1.18 μM. Compounds 7 and 8 showed suppressive effects on NO production with IC50 values of 7.30 ± 0.69 and 5.16 ± 0.17 μM, respectively.
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