Related Experiment Video For Clinical Audit
Updated: May 5, 2026
Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
Implementing recommendations for routine mismatch repair (MMR) immunohistochemistry (IHC) testing of endometrial
Mohamed Shawky1, Maria Murrey1, Jo Morrison2,3
1Gynaecological Oncology, GRACE Centre, Somerset NHS Foundation Trust, Taunton, UK.
Abstract:
Lynch syndrome is associated with an increased risk of cancer, including endometrial cancer. We audited the introduction of a nurse-led testing and management pathway for Lynch syndrome. All 191 patients diagnosed with endometrial cancer at Somerset NHS Foundation Trust between January 2022 and December 2023 were tested for mis-match repair (MMR) protein immunohistochemistry; germline testing was offered to all 13 who were eligible. Seven patients were diagnosed with Lynch syndrome; all were referred for bowel screening and Helicobacter pylori testing. Information about prophylactic aspirin recommendations was missing for 3/7 patients. We established an effective, nurse-led Lynch syndrome testing pathway, in line with national guidelines.
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