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Related Experiment Videos

Growth control by cell to cell contact.

R Bunge, L Glaser, M Lieberman

    Journal of Supramolecular Structure
    |January 1, 1979
    PubMed
    Summary
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    Cell surface membranes control cell growth. Extracts from these membranes, specifically from 3T3 cells, retain the ability to inhibit cell growth, suggesting key molecules are involved.

    Area of Science:

    • Cell Biology
    • Molecular Biology
    • Biochemistry

    Background:

    • Cell-to-cell contact regulates cell growth through mechanisms like contact inhibition and mitogenic stimulation.
    • Two key systems are examined: contact inhibition in Swiss 3T3 cells and Schwann cell stimulation by neurites.

    Purpose of the Study:

    • To investigate the role of cell surface membranes in mediating cell growth control.
    • To determine if the biological effects of cell contact can be replicated using isolated membrane components.

    Main Methods:

    • Studied Swiss 3T3 cells for contact inhibition and Schwann cells stimulated by dorsal root ganglia neurites.
    • Added surface membranes to cells to observe biological effects.
    • Analyzed the correlation between membrane binding and biological activity in 3T3 cells.

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  • Prepared an octylglucoside extract of 3T3 plasma membranes.

    • Main Results:

    • The biological effects of cell contact, including growth inhibition and stimulation, were reproduced by adding surface membranes.
    • For 3T3 cells, biological activity in growth inhibition correlated with membrane binding.
    • An octylglucoside extract of 3T3 plasma membranes retained the growth-inhibitory activity of the original membranes.

    Conclusions:

    • Cell surface membranes play a crucial role in regulating cell growth.
    • Specific molecules within the plasma membrane are responsible for mediating cell growth control signals.
    • Further investigation of membrane-derived factors can elucidate mechanisms of cell proliferation and differentiation.