Related Experiment Video
Updated: May 31, 2025
10:37
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
92
Circulating Proteomic Profiles Are Associated With Incident Type 2 Diabetes in Asian Populations
Yujian Liang1, Charlie G Y Lim1, Scott C Ritchie2,3,4,5,6
1Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore.
The Journal of Clinical Endocrinology and Metabolism
|January 22, 2025
Summary
This study identified 17 key plasma proteins associated with type 2 diabetes (T2D) in Asian populations. These findings offer insights into T2D
Area of Science:
- Proteomics
- Genetics
- Endocrinology
Background:
- Type 2 diabetes (T2D) is a growing global health concern, particularly in Asia.
- Previous proteomic studies on T2D have largely overlooked Asian populations.
- Plasma proteins are crucial biomarkers for understanding disease pathways.
Purpose of the Study:
- To investigate the association between plasma proteins and the incidence of T2D in an Asian cohort.
- To identify specific protein biomarkers linked to T2D development in diverse Asian ethnicities.
Main Methods:
- Analyzed 4,775 plasma proteins in 1,659 Singaporean Asian participants using logistic regression.
- Employed two-sample Mendelian randomization and colocalization analysis to assess causality.
- Adjusted for demographic and clinical risk factors for T2D.
Main Results:
- Identified 522 proteins associated with incident T2D, with 17 remaining significant after adjusting for risk factors.
- Observed changes in 205 proteins correlating with T2D development over time.
- Found enrichment in pathways related to neuron generation and insulin-like growth factor binding.
- Mendelian randomization suggested causal roles for GSTA1, INHBC, and FGL1 in T2D.
Conclusions:
- Discovered distinct plasma protein profiles associated with T2D onset in Asian individuals.
- Provided novel insights into the molecular mechanisms underlying T2D pathogenesis.
- Highlighted potential protein biomarkers for T2D risk stratification in Asian populations.
Related Concept Videos
01:22Diabetes Mellitus: Type 2 and Gestational
2.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K
01:11Genome-wide Association Studies-GWAS
12.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
12.4K
01:15Diabetes: Symptoms, Diagnosis, and Complications
500
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
500
01:36Carbohydrate Metabolism
10.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.8K