Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Comparative function of centrifugal apheresis devices.

G Rock, V Blanchette, N McCombie

    Vox Sanguinis
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Bringing the apheresis world together again.

    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2022
    Same author

    Editor's note.

    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2021
    Same author

    [Multidisciplinary management of diabetic foot ulcer infection].

    La Revue de medecine interne·2021
    Same author

    Baseline characteristics and outcomes of children with cancer in the English-speaking Caribbean: A multinational retrospective cohort.

    Pediatric blood & cancer·2018
    Same author

    Pharmacokinetic modelling and validation of the half-life extension needed to reduce the burden of infusions compared with standard factor VIII.

    Haemophilia : the official journal of the World Federation of Hemophilia·2018
    Same author

    Defining extended half-life rFVIII-A critical review of the evidence.

    Haemophilia : the official journal of the World Federation of Hemophilia·2018

    This study compared four apheresis devices, finding the CS-3000 yielded the most granulocytes but also many platelets. Donor safety was confirmed across all evaluated apheresis systems.

    Area of Science:

    • Hematology
    • Medical Devices
    • Transfusion Medicine

    Background:

    • Apheresis technology is crucial for isolating specific blood components.
    • Evaluating the performance and safety of apheresis devices is essential for clinical practice.

    Purpose of the Study:

    • To compare the performance and safety of four different apheresis devices.
    • To provide data on granulocyte and platelet yields, blood processing volumes, and potential adverse effects.

    Main Methods:

    • Comparative evaluation of four apheresis devices (specific models not detailed beyond CS-3000 and Fenwal bag).
    • Assessment of granulocyte and platelet yields.
    • Measurement of blood volume processed.
    • Analysis of donor return line for adverse effects.

    Related Experiment Videos

  • Evaluation of red cell contamination during plasma exchange.

    • Main Results:

    • The CS-3000 device demonstrated the highest granulocyte yield (1.7 x 10^10 cells) but also a high platelet co-collection (4.5 x 10^11 cells).
    • Plateletpheresis procedures yielded 3.4 x 10^11 to 4.5 x 10^11 cells.
    • Blood processing volumes varied significantly, from 2.4 to 7 liters.
    • No significant adverse effects were observed on the donor return line.
    • Plasma exchange showed minimal red cell contamination, but the Fenwal bag system resulted in significant platelet removal (6.9 x 10^10).

    Conclusions:

    • Apheresis device performance varies, impacting component yields and purity.
    • The CS-3000 is effective for granulocyte collection but requires consideration of concurrent platelet collection.
    • Donor safety appears to be maintained across the evaluated devices.
    • Device selection should be based on specific clinical needs, balancing yield, purity, and processing volume.