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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
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A β-cyclodextrin-based supramolecular modular system creating micellar carriers for codelivery of doxorubicin and

Xichuan Tang1, Yuting Wen2, Zhongxing Zhang1

  • 1Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, 15 Kent Ridge Crescent, Singapore 119276, Singapore.

Carbohydrate Polymers
|January 22, 2025
PubMed

Insights

This study introduces a modular self-assembly system for creating micellar carriers that efficiently codeliver chemotherapy drugs and small interfering RNAs (siRNAs) to target cancer cells and inhibit PD-L1 expression, enhancing cancer therapy.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Therapy

Background:

  • Chemotherapy and gene therapy combination shows promise for cancer treatment.
  • Silencing PD-L1 with small interfering RNAs (siRNAs) can enhance anticancer immunity.
  • Effective codelivery of drugs and genes is challenging due to carrier design and synthesis complexity.

Purpose of the Study:

  • To develop a convenient modular self-assembly system for multifunctional micellar carriers.
  • To achieve efficient codelivery of doxorubicin (Dox) and siRNA for cancer treatment.
  • To create adaptable carriers for drug- and gene-based immune-assisted cancer therapy.

Main Methods:

  • Utilized host-guest interactions between β-cyclodextrin (β-CD) and adamantane (Ad) for micelle formation.
  • Incorporated functional polymer segments like oligoethylenimine (OEI), poly(ethylene glycol) (PEG), and polycaprolactone (PCL) at adjustable ratios.
  • Engineered cationic amphiphilic supramolecular architectures for drug and gene encapsulation.

Main Results:

  • Demonstrated efficient codelivery of Dox and siRNA using the developed micellar carriers.
  • Achieved excellent structural stability, drug and gene loading, and delivery efficiency.
  • Observed significant anticancer effects from Dox delivery and PD-L1 inhibition via siRNA.

Conclusions:

  • The modular supramolecular strategy provides a straightforward approach to create multifunctional micellar carriers.
  • This system enables adaptable and efficient codelivery of drugs and genes for cancer therapy.
  • The developed carriers hold potential for advancing drug- and gene-based immune-assisted cancer treatment.
Keywords:
ChemotherapyCyclodextrinGene therapyHost–guest interactionImmune checkpoint blockadeMicelle

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