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Updated: Aug 19, 2026

Vascular Occlusion Training for Inclusion Body Myositis: A Novel Therapeutic Approach
Published on: June 6, 2010
[Effect of 24-day exercise therapy on induced thrombocyte aggregation in peripheral arterial occlusive disease in
Abstract:
ADP and collagen induced platelet aggregation (PA) was studied in 18 patients suffering from arterial occlusive disease (stage II Fontaine) before and after a standardized treadmill test before and after 24 days of exercise training. At the beginning of this therapy collagen induced PA after treadmill testing was increased (amplitude +11.29%, p less than 0.05, maximal slope +18.57%, p less than 0.05, integrated area +15.23%, p less than 0.05), whereas ADP induced PA showed no consistent alteration. After the 24-day treatment period increase in collagen induced PA was considerably smaller (amplitude +7.48%, n.s., maximal slope +7.35%, n.s., integrated area +11.99%, p less than 0.05), whereas ADP induced PA again showed no consistent changes. Since the treadmill exercise induced PA showed a negative linear correlation with the claudication provoking walking distance the smaller increase in PA after treatment was considered to be due to the improved metabolic situation following exercise therapy.
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