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Updated: Jul 14, 2026

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Reorganization of gray matter networks in patients with Moyamoya disease

Huan Zhu1,2,3,4, Peijiong Wang1,2,3,4, Wenjie Li1,2,3,4

  • 1Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.

Scientific Reports
|January 22, 2025
PubMed

Insights

Moyamaya disease (MMD) patients show altered brain gray matter networks compared to healthy individuals. These changes in network topology and regional connectivity can help detect MMD-related structural brain alterations.

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Systems Biology

Background:

  • Moyamaya disease (MMD) is characterized by cerebrovascular changes, leading to altered brain structure and function.
  • Understanding gray matter network alterations in MMD is crucial for diagnosis and treatment.
  • Previous studies have focused on white matter, with limited insight into gray matter network topology.

Purpose of the Study:

  • To investigate gray matter network topology in MMD patients.
  • To compare network characteristics between MMD patients and healthy controls (HCs).
  • To analyze differences in gray matter networks among MMD subtypes (ischemic, asymptomatic, hemorrhagic).

Main Methods:

  • 136 MMD patients and 99 HCs were enrolled.
  • Gray matter network topology was analyzed using graph theory metrics.
  • Clinical characteristics and regional abnormalities were assessed.

Main Results:

  • MMD patients exhibited decreased clustering coefficient and local efficiency compared to HCs.
  • Ischemic MMD patients showed reduced local efficiency and increased characteristic path length.
  • Significant regional abnormalities in degree centrality and betweenness centrality were observed in MMD patients, with variations across subtypes.

Conclusions:

  • MMD is associated with significant gray matter network reorganization.
  • Gray matter network analysis can effectively detect MMD-related brain structural changes.
  • Network topology differs among MMD subtypes, suggesting distinct pathophysiological mechanisms.
Keywords:
Graph theoryGray Matter NetworkGray Matter volumeMoyamoya DiseaseNetwork-based statistic

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