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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
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Related Experiment Video

Updated: May 31, 2025

PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke
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CD45-PET is a robust, non-invasive tool for imaging inflammation.

Ali Salehi Farid1,2, Jennifer E Rowley1,2, Harris H Allen1

  • 1Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.

Nature
|January 22, 2025
PubMed
Summary

New CD45-PET imaging detects inflammation with high sensitivity, outperforming current methods. This technique precisely monitors disease and shows promise for guiding patient diagnosis and treatment decisions.

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Area of Science:

  • Medical Imaging
  • Immunology
  • Nuclear Medicine

Background:

  • Imaging inflammation is crucial for diagnosing and treating diseases.
  • Current positron emission tomography (PET) probes lack specificity and sensitivity for inflammation detection.

Purpose of the Study:

  • To develop and evaluate CD45-PET imaging as a sensitive and specific tool for detecting and monitoring inflammation.

Main Methods:

  • Developed CD45-PET imaging probes for preclinical and clinical use.
  • Assessed probe sensitivity and specificity in preclinical models of inflammatory lung and bowel diseases.
  • Compared CD45-PET with 18F-fluorodeoxyglucose PET for inflammation imaging.
  • Validated a human CD45-PET probe in a humanized mouse model.

Main Results:

  • CD45-PET imaging demonstrated exceptional sensitivity and clarity in detecting inflammation.
  • CD45-PET signal intensity robustly correlated with disease severity in preclinical models.
  • CD45-PET outperformed 18F-fluorodeoxyglucose PET in detecting inflammation.
  • Longitudinal CD45-PET enabled precise monitoring of dynamic inflammatory changes.
  • A human CD45-PET probe successfully detected human immune cells in vivo.

Conclusions:

  • CD45-PET imaging offers a sensitive and specific method for assessing inflammation.
  • This technique can guide diagnostic and therapeutic decisions for inflammatory diseases.
  • CD45-PET provides precise, whole-body inflammation profiling for individual patients.