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Relationship between platelet distribution width and non-dipping pattern in children with essential hypertension

Ling Sun1, Bo Wang1, Daoping Yang1

  • 1Department of Cardiology, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.

BMC Pediatrics
|January 23, 2025
PubMed

Insights

Essential hypertension in children often shows a non-dipping blood pressure pattern. Higher platelet distribution width, hs-CRP, and triglycerides are linked to this non-dipping status in pediatric hypertension.

Area of Science:

  • Pediatric Cardiology
  • Hypertension Research
  • Clinical Biomarkers

Background:

  • Essential hypertension prevalence is increasing in younger populations.
  • Non-dipping blood pressure patterns are linked to target organ damage.
  • Limited data exists on non-dipper characteristics in pediatric essential hypertension.

Purpose of the Study:

  • To investigate clinical characteristics of non-dipper status in children with essential hypertension.
  • To identify potential indicators associated with non-dipping blood pressure in this pediatric group.

Main Methods:

  • Retrospective study of 125 children with untreated essential hypertension.
  • Definition of non-dipping: nocturnal systolic or diastolic BP drop <10%.
  • Data collected: clinical details, ambulatory blood pressure monitoring (ABPM), lab tests, echocardiography.

Main Results:

  • Non-dipping pattern observed in 59.2% of children.
  • Higher prevalence of left ventricular hypertrophy in the non-dipping group.
  • Elevated platelet distribution width (PDW), hs-CRP, and triglycerides (TG) in non-dippers.

Conclusions:

  • Non-dipping is common in pediatric hypertension.
  • Non-dipping children with hypertension show increased left ventricular hypertrophy.
  • Higher PDW, hs-CRP, and TG levels are risk factors for non-dipping status in pediatric essential hypertension.
Abstract

Keywords:
ChildrenHypertensionLeft ventricular hypertrophyNon-dipping patternPlatelet distribution width

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