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Relationship between platelet distribution width and non-dipping pattern in children with essential hypertension
Ling Sun1, Bo Wang1, Daoping Yang1
1Department of Cardiology, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
BMC Pediatrics
|January 23, 2025
Summary
Essential hypertension in children often shows a non-dipping blood pressure pattern. Higher platelet distribution width, hs-CRP, and triglycerides are linked to this non-dipping status in pediatric hypertension.
Area of Science:
- Pediatric Cardiology
- Hypertension Research
- Clinical Biomarkers
Background:
- Essential hypertension prevalence is increasing in younger populations.
- Non-dipping blood pressure patterns are linked to target organ damage.
- Limited data exists on non-dipper characteristics in pediatric essential hypertension.
Purpose of the Study:
- To investigate clinical characteristics of non-dipper status in children with essential hypertension.
- To identify potential indicators associated with non-dipping blood pressure in this pediatric group.
Main Methods:
- Retrospective study of 125 children with untreated essential hypertension.
- Definition of non-dipping: nocturnal systolic or diastolic BP drop <10%.
- Data collected: clinical details, ambulatory blood pressure monitoring (ABPM), lab tests, echocardiography.
Main Results:
- Non-dipping pattern observed in 59.2% of children.
- Higher prevalence of left ventricular hypertrophy in the non-dipping group.
- Elevated platelet distribution width (PDW), hs-CRP, and triglycerides (TG) in non-dippers.
Conclusions:
- Non-dipping is common in pediatric hypertension.
- Non-dipping children with hypertension show increased left ventricular hypertrophy.
- Higher PDW, hs-CRP, and TG levels are risk factors for non-dipping status in pediatric essential hypertension.
Keywords:
ChildrenHypertensionLeft ventricular hypertrophyNon-dipping patternPlatelet distribution widthMore Related Videos
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