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Updated: May 31, 2025

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MVK, induced by Kras, represses cGAS-Sting signalling in lung adenocarcinoma

Changsheng Zhou1, Jia Liu2, Xudong Hu3

  • 1Departments of Respiratory and Critical Care Medicine, The Affiliated Cangnan Hospital of Wenzhou Medical University, Cangnan, Zhejiang, 325800, China.

European Journal of Medical Research
|January 23, 2025
PubMed

Insights

Mevalonate kinase (MVK) suppresses anti-tumor immunity in lung adenocarcinoma by inhibiting TBK1-mediated signaling. This finding reveals MVK's nonmetabolic role and suggests new therapeutic targets.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Tumor cells exhibit heightened cholesterol metabolism.
  • Metabolic enzymes in cholesterol pathways are upregulated in cancers, but their nonmetabolic roles are largely unknown.
  • Lung adenocarcinoma shows altered cholesterol metabolism.

Purpose of the Study:

  • Investigate the nonmetabolic functions of mevalonate kinase (MVK) in lung adenocarcinoma.
  • Elucidate the molecular mechanisms by which MVK influences the tumor microenvironment.
  • Identify potential therapeutic targets for lung adenocarcinoma.

Main Methods:

  • Analysis of MVK expression in lung adenocarcinoma tissues versus normal tissues.
  • Investigating MVK's interaction with TBK1 and its effect on phosphorylation.
  • Assessing the impact on cGAS-Sting signaling pathway.
  • Correlating MVK expression with CD8+ T-cell infiltration using public database analysis.

Main Results:

  • MVK is upregulated in lung adenocarcinoma and induced by activated Kras.
  • MVK directly interacts with TBK1, inhibiting its phosphorylation and suppressing cGAS-Sting signaling.
  • A negative correlation exists between MVK expression and CD8+ T-cell infiltration.

Conclusions:

  • MVK possesses a critical nonmetabolic function in modulating the tumor immunological microenvironment.
  • MVK's role in suppressing anti-tumor immunity presents a novel therapeutic target for lung adenocarcinoma.
  • Targeting MVK may enhance immune responses against lung adenocarcinoma.
Keywords:
CGAS-Sting signallingKrasLung adenocarcinomaMevalonate kinase

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