Global Delphi consensus on treatment goals for generalized pustular psoriasis

Area of Science:

• Dermatology
• Inflammatory Diseases
• Patient-Reported Outcomes

Background:

• Generalized pustular psoriasis (GPP) is a chronic, systemic, neutrophilic inflammatory disease.
• Previous consensus efforts on GPP lacked patient perspectives and clear treatment goals.

Purpose of the Study:

• To achieve consensus on refined, specific treatment goals for GPP by including patient participation in a Delphi panel.
• To establish overarching principles and short- and long-term treatment objectives for GPP management.

Main Methods:

• A global Delphi panel of 30 dermatologists and 3 patient representatives was convened.
• Statements on GPP treatment goals were developed from a systematic literature review and refined by a Steering Committee.
• Consensus was defined as ≥ 80% approval, with voting conducted in rounds.

Main Results:

• Consensus (≥90% agreement) was reached on 23 of 26 statements in the first round.
• Key findings emphasize timely, tailored, multidisciplinary GPP treatment co-developed by patients and physicians.
• Short-term goals include pustule clearance, symptom reduction, and preventing complications; long-term goals focus on sustained control and improved quality of life.

Conclusions:

• The first global Delphi panel for GPP including patient perspectives achieved consensus on treatment principles and goals.
• Findings highlight the importance of patient-centered care and provide insights for developing inclusive GPP treatment guidelines.