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Area of Science:

  • Clinical research methodology
  • Health services research
  • Translational science

Background:

  • Increasing complexity in clinical research leads to higher costs, longer study times, and challenges in recruitment and generalizability.
  • Clinical research networks (CRN) have emerged as a model to streamline research processes and engage a wider community.
  • The Johns Hopkins Clinical Research Network (JHCRN) was established in 2009 to foster multi-disease collaboration between academic medical centers and community health systems.

Purpose of the Study:

  • To report on the establishment, structure, and outcomes of the Johns Hopkins Clinical Research Network (JHCRN).
  • To illustrate how an academic-community partnership can facilitate clinical research across diverse healthcare settings.
  • To share lessons learned in developing and operating a regional clinical research network.

Main Methods:

  • Established a multi-disease research collaboration involving academic medical centers and community hospitals/health systems.
  • Implemented a centralized governance structure with a single Institutional Review Board (IRB) of record and a dedicated contracting office.
  • Leveraged organized patient communities, community-based investigators, and academic researchers across nine health systems in the mid-Atlantic region.

Main Results:

  • Conducted 81 studies, including clinical trials, cohort studies, and comparative effectiveness research, funded by NIH, foundations, and industry (as of August 2024).
  • Facilitated research partnerships across differing hospital sizes and types within the region.
  • Enhanced understanding of the complexities of participating sites and associated ambulatory practices.

Conclusions:

  • Clinical research networks, as academic-community partnerships, provide essential infrastructure for multi-disease studies.
  • CRNs promote shared risk, increase investigator engagement, and improve volunteer participation.
  • The JHCRN model demonstrates a successful approach to expanding research collaborations and accelerating clinical research delivery.