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Updated: May 2, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
Published on: May 6, 2014
Sortilin as a Culprit in the Atherosclerosis Plaque Progression: Evidence from Clinical and Experimental Studies
Guangyu Cheng1, Jie Liu2, HongLi Zhang2
1The Sixth Department of acupuncture and moxibustion, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, China.
Abstract:
Sortilin acts as a key receptor for lipids, growth factors, cytokines, and enzymes and participates in pathological cargo loading and transferring of extracellular vesicles. Emerging evidence suggests a significant role of sortilin in hyperlipidemia and the risk of atherosclerosis. Recent epidemiological evidence demonstrated that sortilin has been implicated in atherosclerosis plaque progression in patients with coronary or peripheral artery disease. The present study presents a comprehensive review of the contribution of sortilin to atherosclerosis progression. Here, recent experimental and clinical findings are summarized to determine the effects of sortilin on atherosclerosis progression and the related underlying mechanisms.
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