Recent Advances in the Development of Greener Methodologies for the Synthesis of Benzothiazoles

The benzothiazole ring system has been recognised with crucial pharmacophoric features being present among various approved drugs and clinical and pre-clinical candidates. The medicinal importance of this privileged scaffold stimulated the interest of synthetic medicinal/ organic chemists for the synthesis of its derivatives due to their diverse biological applications. In most of the reports in the literature, benzothiazoles were synthesized by cyclocondensation of 2- aminothiophenol with either carboxylic acid and its derivatives or aldehydes. However, many of these procedures involve reaction conditions that are not in conformity with sustainable chemistry development. The negative impact of chemicals and their manufacturing processes on the environment, human health, and biodiversity raises safety concerns. On the other hand, the utilization of non-renewable energy sources, use of rare earth metals as catalysts, involvement of costly chemicals, prolonged reaction time at high temperatures, and considerable waste generation diminish the greener impact of these reaction methodologies and make them non-sustainable. In order to avoid such drawbacks of the non-sustainable practices in the synthesis of benzothiazoles, there have been continuous efforts to develop greener methodologies for the construction of this bioactive scaffold. This review aims to delve into the literature reports on the recent advancements in the development of greener methodologies for the synthesis of bioactive benzothiazoles.