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Cells and Secretions of the Pancreas

Cells and Secretions of the Pancreas

The pancreas, a vital organ within the abdominal cavity, plays dual roles in the digestive and endocrine systems, collaborating with exocrine and endocrine cells to maintain optimal digestion and blood sugar levels.
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
Concurrently, the dispersed clusters of endocrine cells throughout the...

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Related Experiment Video

Updated: May 31, 2025

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro

Published on: June 2, 2018

Recreating the Endocrine Niche: Advances in Bioengineering the Pancreas.

Laura Mar Fonseca^1,2,3, Nicerine Krause^1,2,3, Fanny Lebreton^1,2,3

¹Laboratory of Tissue Engineering and Organ Regeneration, Department of Surgery, University of Geneva, Geneva, Switzerland.

Artificial Organs

|January 23, 2025

Summary

Intrahepatic islet transplantation shows promise for Type 1 Diabetes, but faces challenges like cell loss and immune rejection. Bioengineering strategies aim to recreate the natural endocrine niche for improved islet survival and function.

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Author Spotlight: Advancing Type 1 Diabetes Research Using Innovative Pancreatic Slice Platforms

Author Spotlight: Advancing Type 1 Diabetes Research Using Innovative Pancreatic Slice Platforms

Published on: March 15, 2024

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Last Updated: May 31, 2025

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro

Published on: June 2, 2018

Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation

Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation

Published on: August 7, 2015

Author Spotlight: Advancing Type 1 Diabetes Research Using Innovative Pancreatic Slice Platforms

Author Spotlight: Advancing Type 1 Diabetes Research Using Innovative Pancreatic Slice Platforms

Published on: March 15, 2024

Area of Science:

Regenerative Medicine
Bioengineering
Endocrinology

Background:

Intrahepatic islet transplantation is a key strategy for Type 1 Diabetes treatment.
Current limitations include donor organ scarcity, islet loss during isolation (anoikis, hypoxia), and immune rejection.
Existing approaches focus on revascularization, extracellular matrix (ECM) support, alternative cell sources, and immunomodulation.

Purpose of the Study:

To review strategies for bioengineering a functional endocrine pancreas.
To emphasize the critical role of recreating the native endocrine niche for successful islet transplantation.
To address the gap in integrating structural and functional aspects for clinical translation.

Main Methods:

Discussion of bioengineering techniques to promote revascularization and ECM support.
Exploration of alternative insulin-secreting cell sources.
Review of immunomodulation strategies for graft protection.

Main Results:

Advancements in creating vascularized and immune-protected insulin-secreting constructs.
Highlighting the importance of the endocrine niche's composition and function.
Identification of a gap in cohesive strategies that replicate the native endocrine environment.

Conclusions:

Bioengineering an endocrine pancreas requires recreating the endocrine niche for long-term efficacy.
Comprehensive methods are needed to address both structural and functional aspects of the niche.
Achieving lifelong efficacy and insulin independence necessitates a holistic approach to endocrine niche replication.