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Primary medullary adenocarcinoma of the colon: Literature review and case series

  • 0Faculty of Medicine University of Tasmania, Tasmania, Australia.
Surgery in Practice and Science +

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January 23, 2025

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January 23, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Medullary colon cancer, a rare subtype, shows a favorable prognosis and is linked to deficient mismatch repair. This study compares a local cohort to existing literature, finding similar characteristics.

Area Of Science

  • Gastroenterology
  • Oncology
  • Pathology

Background

  • Medullary carcinoma of the colon is a rare adenocarcinoma subtype.
  • It presents a favorable prognosis compared to poorly differentiated cancers.
  • This subtype is associated with deficient mismatch repair (dMMR).

Purpose Of The Study

  • To analyze clinical and pathological features of medullary colon cancer.
  • To compare a single-center cohort with existing literature data.
  • To investigate the association with deficient mismatch repair.

Main Methods

  • Retrospective review of 11 medullary colon cancer patients (2016-2023).
  • Literature search using PubMed for medullary carcinoma of the colon/colorectum.
  • Comparison of patient demographics, tumor characteristics, and molecular markers.

Main Results

  • The local cohort (11 patients) showed similarities to literature data (3144 patients).
  • Female predominance (81.8%) and high rates of lympho-vascular invasion were observed.
  • All patients exhibited loss of MLH1/PMS2, consistent with dMMR.

Conclusions

  • The studied cohort of medullary colon cancer patients mirrors literature findings.
  • Further follow-up is needed to assess long-term survival outcomes.
  • Deficient mismatch repair is a key characteristic of this cancer subtype.

Keywords: