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Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

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Updated: May 31, 2025

Adsorption Device Based on a Langatate Crystal Microbalance for High Temperature High Pressure Gas Adsorption in Zeolite H-ZSM-5

Adsorption Device Based on a Langatate Crystal Microbalance for High Temperature High Pressure Gas Adsorption in Zeolite H-ZSM-5

Published on: August 25, 2016

Optimized heparin adsorption using macroporous zeolites: A comprehensive study.

Katelyn R Reid¹, Alireza Tabibi², Parisa Adami³

¹Department of Physical and Environmental Sciences, Texas A&M University Corpus Christi, Corpus Christi, TX, 78412, USA.

|January 23, 2025

Summary

This summary is machine-generated.

This study explores zeolites as cost-effective adsorbents for heparin extraction from porcine intestinal mucosa. CBV901 zeolite demonstrated high efficiency and capacity for heparin recovery, suggesting its potential for pharmaceutical applications.

Keywords:

Heparin Heparin adsorption Kinetic and thermodynamics Plasma-derived Porcine mucosa Porous adsorbents Y-zeolites adsorption Zeolite

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Area of Science:

Biomaterials Science
Pharmaceutical Chemistry
Adsorption Technology

Background:

Heparin is a vital pharmaceutical ingredient extracted from porcine intestinal mucosa.
Traditional extraction methods use commercial resins, prompting research into cost-effective alternatives.
Zeolites, with their high surface area and porosity, are promising candidates for adsorbent applications.

Purpose of the Study:

To evaluate the efficacy of two zeolites, CBV901 and CBV10A, for heparin recovery.
To determine the adsorption capacity and efficiency of selected zeolites.
To analyze the adsorption mechanism and optimize the recovery process.

Main Methods:

Screening of CBV901 and CBV10A zeolites for heparin adsorption from porcine intestinal mucosa.
Quantification of heparin adsorption efficiency and capacity.
Kinetic and thermodynamic modeling to understand adsorption mechanisms.
Investigation of adsorption time and sorbent reusability.

Main Results:

CBV901 zeolite achieved 44% efficiency and 23.3 mg/g adsorption capacity for heparin.
Kinetic and thermodynamic analyses indicated favorable surface conditions for heparin adsorption.
Adsorption parameters and sorbent reusability were assessed for process refinement.

Conclusions:

CBV901 zeolite shows significant potential as an efficient and cost-effective adsorbent for heparin extraction.
The study provides valuable insights into zeolite-based heparin recovery processes.
Further optimization could enhance the industrial applicability of this method.