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Identification of the Skip Phenomenon Among Patients With Staphylococcus lugdunensis Infective Endocarditis: A

Patrick D Crowley1, Luis R Gasca2, Silpita Katragadda1

  • 1Division of Public Health, Infectious Disease, and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Open Forum Infectious Diseases
|January 23, 2025
PubMed

Insights

The skip phenomenon, where blood cultures intermittently turn positive, occurred in one-third of Staphylococcus lugdunensis infective endocarditis cases. This pattern was linked to longer bacteremia, extended hospital stays, and increased mortality.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Microbiology

Background:

  • The skip phenomenon (SP) describes intermittent positive blood cultures before pathogen clearance.
  • Staphylococcus lugdunensis is a significant cause of infective endocarditis.
  • Understanding SP patterns in S. lugdunensis endocarditis is crucial for patient management.

Purpose of the Study:

  • To investigate the occurrence and clinical implications of the skip phenomenon in patients with Staphylococcus lugdunensis infective endocarditis.
  • To determine if SP is associated with specific clinical outcomes.

Main Methods:

  • Retrospective analysis of patients diagnosed with Staphylococcus lugdunensis infective endocarditis.
  • Identification of patients who exhibited the skip phenomenon based on blood culture results.
  • Comparison of clinical characteristics and outcomes between patients with and without the skip phenomenon.

Main Results:

  • One-third of patients with Staphylococcus lugdunensis infective endocarditis experienced the skip phenomenon.
  • Patients with the SP had a longer duration of bacteremia.
  • Patients with the SP also had a longer hospital stay and a higher 1-year mortality rate.

Conclusions:

  • The skip phenomenon is a notable pattern in Staphylococcus lugdunensis infective endocarditis.
  • Experiencing the SP is associated with poorer clinical outcomes, including prolonged illness and increased mortality.
  • Recognition of the SP in S. lugdunensis endocarditis may guide treatment adjustments and prognostication.
Keywords:
Staphylococcus lugdunensisbacteremiablood cultureinfective endocarditisskip phenomenon

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