Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pretemporal and Posterior Petrosal Approaches to the Retroinfundibular Region: A Quantitative and Comparative Cadaveric Study.

Operative neurosurgery (Hagerstown, Md.)·2026
Same author

Genetic and transcriptomic signatures of host control in HIV-1 infection.

Retrovirology·2026
Same author

Perceptions of mental health services among informal caregivers in Sardinia, Italy, during the post-pandemic crisis of the national health system: a comparative study between 2024 and 2025.

Frontiers in psychiatry·2026
Same author

The perception of quality of care and respect of human rights in mental healthcare facilities among users during and after the pandemic in Sardinia, Italy.

Frontiers in public health·2026
Same author

Physicians shortage in primary care: a protocol for updating a systematic review of recruitment and retention strategies.

F1000Research·2026
Same author

International Expert Priorities for Promoting Recovery and Coercion-Free Practices in Psychosocial Disability: A Delphi Study.

Alpha psychiatry·2026
Same journal

Complication assessment in full-endoscopic uniportal lumbar spine surgery: A prospective analysis from 304 patients.

Brain & spine·2026
Same journal

Not all enhancing lesions are tumor recurrence: Foreign body granulomas after glioma resection.

Brain & spine·2026
Same journal

First 100 brachial plexus surgeries in Angola: Population impact and lessons learned.

Brain & spine·2026
Same journal

Recommendations for ventriculostomy and cisternostomy in TBI management: Results of the WFNS-Neurotraumatology committee "Cusco consensus".

Brain & spine·2026
Same journal

Secondary risks of bleeding and associated outcome after tirofiban application during interventional treatment of intracranial aneurysms.

Brain & spine·2026
Same journal

Incidence and impact of intracranial complications in patients undergoing extracorporeal membrane oxygenation treatment.

Brain & spine·2026
See all related articles

Related Experiment Video

Updated: May 31, 2025

Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients
07:43

Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients

Published on: September 25, 2018

10.5K

PD-L1 expression in PitNETs: Correlations with the 2022 WHO classification.

Ethan Harel1, Ekkehard Hewer2, Stefano La Rosa3

  • 1Division of Neurosurgery, Department of Clinical Neurosciences, University Hospital of Lausanne and University of Lausanne, Lausanne, Switzerland.

Brain & Spine
|January 23, 2025
PubMed
Summary
This summary is machine-generated.

Programmed death-ligand 1 (PD-L1) expression is linked to Pit-1 lineage in pituitary neuroendocrine tumors (PitNETs), but not to proliferation. PD-L1 is downregulated in SF-1 lineage PitNETs, suggesting differential biological behavior.

Keywords:
2022 WHO classification of PitNETsPD-L1Pit-NETsPituitary adenomaPituitary neuroendocrine tumorsTranscription factors

More Related Videos

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
09:32

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

14.5K
Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction
10:18

Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction

Published on: July 7, 2023

1.2K

Related Experiment Videos

Last Updated: May 31, 2025

Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients
07:43

Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients

Published on: September 25, 2018

10.5K
Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
09:32

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

14.5K
Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction
10:18

Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction

Published on: July 7, 2023

1.2K

Area of Science:

  • Endocrinology
  • Oncology
  • Immunology

Background:

  • Prognostic factors for pituitary neuroendocrine tumors (PitNETs) are limited.
  • Programmed death-ligand 1 (PD-L1) expression shows prognostic value in other neuroendocrine neoplasms.

Purpose of the Study:

  • To analyze PD-L1 expression in PitNETs based on the 2022 WHO classification.
  • To assess the correlation between PD-L1 expression and key transcription factors (T-pit, Pit-1, SF-1, GATA-3).
  • To evaluate the association of PD-L1 expression with proliferation indexes in PitNETs.

Main Methods:

  • Retrospective analysis of 88 PitNET patients.
  • Immunohistochemistry to quantify PD-L1 expression as tumor proportion score (TPS).
  • Correlation analysis with transcription factors (T-pit, Pit-1, SF-1, GATA-3) and proliferation markers.

Main Results:

  • PD-L1 expression positively correlated with Pit-1 lineage (p < 0.001) and specific tumor subtypes (mammosomatotroph, somatotroph, lactotroph) with distinct TPS cut-offs.
  • PD-L1 expression was negatively associated with SF-1 and GATA3 expression (p < 0.001).
  • No association was found between PD-L1 and proliferation indexes; however, PD-L1 expression was linked to female sex and younger age at diagnosis.

Conclusions:

  • PD-L1 expression is associated with the Pit-1 lineage and downregulated in SF-1 lineage PitNETs.
  • PD-L1 expression does not correlate with proliferative factors in PitNETs.
  • Further research is needed to confirm the role of PD-L1 in PitNET behavior.