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Microfluidics in Assessing Platelet Function
06:47

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Plasma thrombin generation kinetics in trauma patients across the age spectrum

Julie Goswami1,2, Taleen A MacArthur1, Cillian R Mahony1

  • 1Department of Surgery, Mayo Clinic, Division of Trauma, Critical Care, and General Surgery, 200 1st St. SW, Rochester, MN 55905, United States.

Surgery in Practice and Science
|January 23, 2025
PubMed

Insights

Age significantly impacts thrombin generation kinetics in trauma patients, with older individuals showing prolonged initiation and peak times. These findings highlight age-related differences in coagulation post-injury, potentially influencing thrombotic risk.

Area of Science:

  • Coagulation science
  • Trauma research
  • Geriatric medicine

Background:

  • Traumatic injury alters coagulation, increasing long-term thrombotic risk.
  • The influence of age on coagulation biomarkers post-trauma is not well understood.
  • Thrombin generation kinetics predict venous thromboembolism.

Purpose of the Study:

  • To investigate age-related differences in thrombin generation kinetics.
  • To characterize thrombin generation in trauma patients across the age spectrum.

Main Methods:

  • Collected plasma samples from 174 trauma patients (ages 3-94).
  • Measured thrombin generation kinetics using calibrated automated thrombogram (CAT), assessing lag time (LT) and time to peak (ttPeak).
  • Analyzed data using Kruskal-Wallis, Spearman correlation, and multivariable regression.

Main Results:

  • Pediatric patients exhibited shorter LT and ttPeak compared to adults and geriatrics.
  • LT and ttPeak significantly correlated with patient age (p < 0.001).
  • Age, injury severity score, and transfusion status were associated with LT and ttPeak in multivariable models.

Conclusions:

  • Trauma patients demonstrate age-dependent prolongation of thrombin generation initiation and peak.
  • Further research is required to elucidate the role of age-specific thrombin generation in post-trauma thrombotic complications.
Abstract

Keywords:
CoagulopathyGeriatricPediatricThrombinTrauma

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