SYSTEMIC INFLAMMATORY MARKERS - PROGNOSTIC VALUE IN OVARIAN CANCER

Area of Science:

• Oncology
• Inflammation Biology
• Cancer Biomarkers

Background:

• Chronic inflammation is a key factor in ovarian cancer development.
• Systemic inflammation markers are increasingly recognized for their role in various cancers.

Purpose of the Study:

• To assess systemic inflammation markers as predictive and prognostic factors in ovarian cancer patients.
• To evaluate the correlation of these markers with clinical and treatment characteristics.

Main Methods:

• Retrospective analysis of 60 ovarian cancer patients undergoing primary cytoreduction surgery.
• Analysis of systemic inflammation markers, including neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and lymphocyte-monocyte ratio (LMR).
• Correlation with clinical data and evaluation as prognostic factors for overall survival.

Main Results:

• No significant correlation found between inflammation markers and age, reproductive status, FIGO stage, or cytoreduction type.
• Higher NLR and PLR were associated with increased mortality.
• Lower LMR was significantly associated with survival in ovarian cancer patients.
• Multivariate analysis showed NLR increased death risk by 9.7%, while LMR reduced it by 46.9%.

Conclusions:

• Systemic inflammation markers, particularly NLR and LMR, are significant prognostic factors for overall survival in ovarian cancer.
• NLR is an independent risk factor, while LMR is an independent protective factor.
• These markers offer valuable insights into patient prognosis irrespective of clinical or surgical details.