Insight into interplay between PANoptosis and autophagy: novel therapeutics in ischemic stroke
He-Yan Tian1, Yun-Xing Lei1, Jing-Tao Zhou1
1School of Medical Technology and Nursing, Shenzhen Polytechnic University, Shenzhen, China.
Abstract:
PANoptosis is a novelly defined mode of programmed cell death that involves the activation of multiple cellular death pathways, including pyroptosis, apoptosis, and necroptosis, triggering robust inflammatory reactions. Autophagy is a crucial cellular process that maintains cellular homeostasis and protects cells from various stresses. PANoptosis and autophagy, both vital players in the intricate pathological progression of ischemic stroke (IS), a brain ailment governed by intricate cell death cascades, have garnered attention in recent years for their potential interplay. While mounting evidence hints at a crosstalk between these two processes in IS, the underlying mechanisms remain elusive. Therefore, this review delves into and dissects the intricate mechanisms that underpin the intersection of PANoptosis and autophagy in this devastating condition. In conclusion, the crosstalk between PANoptosis and autophagy in IS presents a promising target for the development of novel stroke therapies. Understanding the interplay between these two pathways offers a much-needed insight into the underlying mechanisms of IS and opens the possibility for new therapeutic strategies.
Insights
PANoptosis and autophagy are key cell death processes in ischemic stroke (IS). Their interaction offers new therapeutic targets for stroke treatment.
Area of Science:
- Neuroscience
- Cell Biology
- Pathology
Background:
- PANoptosis, a programmed cell death mode, integrates pyroptosis, apoptosis, and necroptosis, inducing inflammation.
- Autophagy is vital for cellular homeostasis and stress response.
- Ischemic stroke (IS) involves complex cell death pathways, with growing interest in PANoptosis and autophagy interplay.
Purpose of the Study:
- To review and analyze the intricate mechanisms of PANoptosis and autophagy intersection in ischemic stroke.
- To elucidate the crosstalk between these two crucial cellular processes in IS pathogenesis.
Main Methods:
- Literature review and analysis of existing research on PANoptosis, autophagy, and ischemic stroke.
- Dissection of molecular mechanisms underlying the interplay between PANoptosis and autophagy in IS.
Main Results:
- Evidence suggests a significant crosstalk between PANoptosis and autophagy in the context of ischemic stroke.
- The precise mechanisms governing this interaction are still under investigation but are crucial for understanding IS pathology.
Conclusions:
- The interplay between PANoptosis and autophagy in IS represents a promising therapeutic target for novel stroke treatments.
- Understanding this crosstalk provides critical insights into IS mechanisms and potential new therapeutic strategies.
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