Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

176
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
176
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

217
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
217
Inhaled Medications01:23

Inhaled Medications

236
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
236
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

349
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
349
Chronic Obstructive Pulmonary Disease-V: Management01:29

Chronic Obstructive Pulmonary Disease-V: Management

2.5K
Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
2.5K
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DSM-5 Changes, COVID-19, and ADHD Diagnosis Rates in Individuals Younger Than 30 Years.

JAMA network open·2026
Same author

Stopping antidepressants safely.

African journal of primary health care & family medicine·2026
Same author

Pharmacotherapy for hypertension in adults 60 years or older.

The Cochrane database of systematic reviews·2025
Same author

Barriers and facilitators to reducing overuse of thyroid function testing: a mixed-methods study.

BMJ quality & safety·2025
Same author

Tramadol (with or without acetaminophen) efficacy and harm: Systematic review and meta-analysis.

Canadian family physician Medecin de famille canadien·2025
Same author

Prevalence of vision impairment and refractive error in rural Nepalese children under five years of age.

Clinical & experimental optometry·2025
Same journal

Corrigendum: A Delphi study to guide the development of a clinical indicator tool for palliative care in South Africa.

African journal of primary health care & family medicine·2026
Same journal

Knowledge and compliance related to the prevention of mother-to-child transmission guidelines amongst South African healthcare professionals.

African journal of primary health care & family medicine·2026
Same journal

Experiences of volunteers: A volunteer-led community strategy for lung cancer awareness and mobilisation in KwaZulu-Natal.

African journal of primary health care & family medicine·2026
Same journal

Evaluating knowledge and awareness of cervical cancer, human papillomavirus and human papillomavirus vaccination among women in East London, South Africa.

African journal of primary health care & family medicine·2026
Same journal

Understanding barriers to treatment-seeking in Mseleni joint disease: A multistaged study in rural KwaZulu-Natal, South Africa.

African journal of primary health care & family medicine·2026
Same journal

Healthcare workers' perspectives on patient bypassing of Primary Health Care facilities in Mpumalanga province, South Africa.

African journal of primary health care & family medicine·2026
See all related articles

Related Experiment Video

Updated: May 31, 2025

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

40.6K

Minimising inhaled corticosteroids for COPD.

Benji Heran1, Thomas L Perry, Ken Bassett

  • 1Department of Anaesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver. bsheran@mail.ubc.ca.

African Journal of Primary Health Care & Family Medicine
|January 23, 2025
PubMed
Summary
This summary is machine-generated.

Inhaled corticosteroids (ICS) offer limited benefits for Chronic Obstructive Pulmonary Disease (COPD) and carry risks. Guidelines now advise limiting ICS to severe COPD cases with frequent exacerbations.

Keywords:
chronic obstructive airways diseasechronic obstructive pulmonary diseasecorticosteroidsinhaled steroidsprimary caretherapeutics

More Related Videos

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
00:07

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Published on: August 24, 2019

9.6K
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

31.8K

Related Experiment Videos

Last Updated: May 31, 2025

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

40.6K
Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
00:07

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Published on: August 24, 2019

9.6K
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

31.8K

Area of Science:

  • Pulmonology
  • Pharmacology
  • Clinical Medicine

Background:

  • Inhaled corticosteroids (ICS) are used for Chronic Obstructive Pulmonary Disease (COPD) symptom management.
  • Randomized trials show limited impact of ICS on COPD mortality and quality of life.
  • ICS use in COPD is associated with potential serious harms.

Purpose of the Study:

  • To review the evidence for inhaled corticosteroids (ICS) in treating Chronic Obstructive Pulmonary Disease (COPD).
  • To evaluate the benefits versus risks of ICS therapy in COPD patients.
  • To provide guidance on appropriate ICS use and deprescribing in COPD.

Main Methods:

  • Review of randomized trials and clinical guidelines on ICS for COPD.
  • Analysis of benefits (symptoms, exacerbations) versus harms (pneumonia, fractures).
  • Consideration of patient factors like COPD severity and exacerbation frequency.

Main Results:

  • ICS provide limited benefits for COPD symptoms and exacerbations.
  • Long-term ICS use increases the risk of serious adverse events like pneumonia and fractures.
  • Guidelines recommend restricting ICS to severe COPD with frequent exacerbations.

Conclusions:

  • The risks of ICS often outweigh benefits in mild COPD.
  • Deprescribing ICS is safe for stable patients with infrequent exacerbations.
  • Initial COPD treatment should prioritize bronchodilators over ICS.