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Published on: February 27, 2014
Mannuronate Oligosaccharides Ameliorate Experimental Colitis and Secondary Neurological Dysfunction by Manipulating
Shuang Lu1, Zhengxiong Tao1, Gan Wang1
1College of Life Science, South-Central Minzu University, No. 182, Minyuan Road, Hongshan District, Wuhan 430074, China.
Abstract:
Microbiota dysfunction induces intestinal disorders and neurological diseases. Mannuronate oligosaccharides (MAOS), a kind of alginate oligosaccharide (AOS), specifically exert efficacy in shaping gut microbiota and relieving cognitive impairment. However, the key regulatory factors involved, such as the specific strains and metabolites as well as their regulatory mechanisms, remain unclear at present. This research investigates how MAOS specifically impact the gut-brain axis in vivo and in vitro. The results showed that pretreatment with MAOS significantly ameliorated dextran sodium sulfate (DSS)-induced colitis and secondary nerve injury. This preventive mechanism operates through the regulation of serum DOPC abundance and the gut-brain axis, achieved by inhibiting the TLR4/MyD88/NF-κB pathway. These findings underscore the crucial role of dietary MAOS in the prevention of colitis and neurological disorders, providing a rationale for the application of MAOS in disease prevention and functional food ingredients.
Insights
Mannuronate oligosaccharides (MAOS) prevent gut and brain diseases by regulating gut microbiota and inhibiting inflammatory pathways. These findings support MAOS as functional food ingredients for disease prevention.
Area of Science:
- Gut microbiota
- Neuroscience
- Alginate oligosaccharides
Background:
- Microbiota dysfunction is linked to intestinal and neurological disorders.
- Mannuronate oligosaccharides (MAOS), a type of alginate oligosaccharide (AOS), show potential in modulating gut microbiota and cognitive function.
- The precise mechanisms and regulatory factors of MAOS in the gut-brain axis are not fully understood.
Purpose of the Study:
- To investigate the effects of MAOS on the gut-brain axis in vivo and in vitro.
- To identify key regulatory factors and mechanisms involved in MAOS-mediated protection.
- To explore the potential of MAOS in preventing colitis and neurological disorders.
Main Methods:
- In vivo and in vitro experiments were conducted.
- Dextran sodium sulfate (DSS)-induced colitis model was used.
- The TLR4/MyD88/NF-κB signaling pathway was analyzed.
Main Results:
- MAOS pretreatment significantly alleviated DSS-induced colitis and secondary nerve injury.
- MAOS regulated serum 1,2-dipalmitoylphosphatidylcholine (DOPC) abundance.
- MAOS inhibited the TLR4/MyD88/NF-κB pathway, impacting the gut-brain axis.
Conclusions:
- Dietary MAOS play a crucial role in preventing colitis and neurological disorders.
- MAOS exert protective effects by modulating the gut-brain axis via the TLR4/MyD88/NF-κB pathway.
- MAOS demonstrate potential as functional food ingredients for disease prevention.
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